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For example, cell-free mtDNA is sensed by TLR9 in endosomes (recognizing CpG DNA) and by Cyclic GMP-AMP synthase (cGAS) in the cytosol (recognizing DNA in general), leading to production of inflammatory cytokines and interferons (1114)

Never leave either peptide at room temperature for more than 30 minutes during preparation or transport temperature excursions above 8C cause irreversible protein denaturation that renders the medication ineffective even if it looks normal

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