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Wu, J., Pan, X., Fu, H., Zheng, Y., Dai, Y., Yin, Y., Chen, Q., Hao, Q., Bao, D., & Hou, D

Tirzepatide 15 mg produced 5.5 kg more weight loss than semaglutide 1 mg (p 25,000 participants in the SURPASS and SURMOUNT programs [1, 2, 3]: Gastrointestinal effects (most common, dose-dependent): Nausea: 12-18% (5 mg), 15-22% (10 mg), 18-28% (15 mg) vs

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These data together suggest that mutation of the non-acidic to an acidic residue at the corresponding 222 position played a key role in the evolution of arogenate-specific TyrA a enzymes in microbes from clade I that gave rise to plant TyrAs