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doi: 10.1023/a:1025968502527

Postprandial glucose excursions are significantly blunted with the addition of pramlintide (427)

Glutamine is degraded into ammonia in the intestine and kidneys, achieving its partial excretion.15 At the level of the brain, hyperammonemia conditions an increase in glutamine synthetase activity, and by exceeding the metabolic capacity of the astrocyte, conditions intracellular osmolarity alterations with later edema, cytolysis, and proinflammatory cytokine release

Two days after plating, various concentrations of glucose, GLP-1, and 007-AM in the modified Krebs-Ringer bicarbonate HEPES buffer (KRBH: 129-mM NaCl, 5-mM NaHCO 3 , 4.8-mM KCl, 1.2-mM KH 2 PO 4 , 1.2-mM MgSO 4 , 10-mM HEPES, 1-mM CaCl 2 ) containing 0.1% (v/v) BSA and 0.1-mM glucose were administered to the cells, which were then incubated for 1 h

(B) Insulin secretion during the IPGTT was measured in mGlp-1r , hGLP-1R, and Glp-1r / mice