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doi: 10.1038/nrgastro.2017.72 11 UsamiMMiyoshiMYamashitaH

10.3934/Neuroscience.2021021 79 PhielixE.MensinkM

A meta-analysis of 15 studies and 15,498 subjects found an increased relative risk of HTN with higher circulating TMAO levels (1.14, 95% CI 1.081.20), and although the RR is relatively small for such a large sample size, this relationship was dose-dependent with a 1.014% increase in HTN risk for every increase of TMAO level by 1 mol/L [70]

The economic value proposition markedly enhances when accounting for the avoidance of long-term problems

Therefore, TIR is considered an ineffective strategy for addressing DXN-induced cognitive deficits and oxidative stress

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