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Angiotensin-converting enzyme 2 metabolizes and partially inactivates Pyr-Apelin-13 and Apelin-17: physiological effects in the cardiovascular system

Within hours of administration, BDNF and its receptor TrkB increase in the hippocampus

GLP-1 and GLP-1 RA (such as Exenatide and Liraglutide) were shown to have an anti-inflammatory action by reducing monocyte adhesion and macrophage accumulation, thus stabilizing atherosclerotic plaque, and slowing atherosclerosis in animal models [47,48,49]

Gastrointestinal symptoms have also been reported, including heartburn, abdominal pain, belching, nausea, vomiting, flatulence, constipation, and diarrhea (106)

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