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Bass and team have some solutions

[1] The most frequently reported adverse effects in clinical trials were gastrointestinal in nature, including nausea (12-22%), diarrhea (12-16%), vomiting (6-10%), and constipation (6-7%), with rates varying by dose

Cardiorenal protection with the newer antidiabetic agents in patients with diabetes and chronic kidney disease: A scientific statement from the American Heart Association

The straight answer: They're not going to work like prescription medications