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Semaglutide reduced carbohydrate intake, weight and weight-based insulin requirements (a marker of insulin sensitivity), all of which improve glycemic control

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The addition of glucagon receptor agonism is particularly notable: preclinical evidence and early human data suggest it may increase energy expenditure and promote fat breakdown (lipolysis), potentially offering greater weight reduction than dual agonists alone though the precise contribution of each receptor in humans remains an active area of research

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