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Langer, H

There is no human trial that sets a timeline, so reports are anecdotal and drawn from animal research

Clinical studies utilizing facial application of 2-3% GHK-Cu serums over 12-week periods have documented measurable improvements across multiple photoaging parameters, including 20-35% reductions in fine line depth, 15-25% improvements in skin elasticity measurements, and 25-40% increases in dermal density as assessed through high-frequency ultrasound imaging

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& Tremblay, M

Melatonin in the treatment of fibromyalgia symptoms: a systematic review