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Based on the significant unmet need in Alzheimers disease as well as a number of indicative data points, we felt we had a responsibility to explore semaglutides potential, despite a low likelihood of success, Martin Holst Lange, chief scientific officer at Novo Nordisk said in a press release

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However, the chemical composition of GSH does not allow it to be taken orally for central nervous system diseases because little to none crosses the blood-brain barrier

For more information about how these drugs compare, see this article

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Since mitochondria cannot synthesize the negatively charged GSH, SLC25A39 is crucial for maintaining GSH homeostasis within the mitochondria [24]