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Systems were equilibrated in isothermal-isobaric conditions (NPT) using the Berendsen barostat 51 with a target pressure of 1 atm, the Langevin thermostat 52 with a target temperature of 310 K, along with a low damping factor of 1 ps 1 and an integration time step of 2 fs

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Retatrutide, by contrast, is still investigational and only available through clinical trials

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Histone Kla is sensitive to lactate levels: inhibiting glycolysis impairs lactate production, subsequently reducing Kla, while increased lactate production elevates Kla levels (130)

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