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Furthermore, FMO3 suppression and overexpression were shown to directly impact systemic TMAO levels, platelet reactivity, and thrombosis rates in a murine model of FeCl 3 -induced carotid artery injury (Zhu et al., 2018)

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However, abnormal platelet activation and aggregation can lead to thrombosis, which is the underlying cause of many cardiovascular events such as myocardial infarction, ischemic stroke, and peripheral arterial disease

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