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In the study of glioblastoma, RSL3 inhibits the activity of GPX4, drives the occurrence of ferrozois and induces oxidative death of glioblastoma cells, providing new therapeutic ideas for glioblastoma (Xu et al., 2021)

Additionally, ROS-mediated peroxidation of lipids triggers ferroptosis by inducing oxidative damage to PUFAs [76]

Catching these early makes them far easier to manage