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Timing is often critical for this medication to be effective

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Many studies found beneficial effects of NAC in COPD patients (reviewed in [98]), although the efficacy of NAC in reducing disease severity was ascribed to NACs mucolytic activity rather than its function as GSH precursor [97]

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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant