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Although DHA has been approved by the FDA for topical use, recent findings suggest that systemic exposure is not negligible

While Phase II trials in heart failure and primary mitochondrial myopathy did not meet primary efficacy endpoints, the TAZPOWER trial in Barth syndrome demonstrated significant improvements in muscle strength and sixminute walk distance, leading to FDA accelerated approval in 2025 [3] [10]

That gives the collagen peptides enough time to build up in your tissues and start making a real structural impact

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This binding is quite tight and facilitates their excretion via the urine

Int.J Clin Pharmacol.Ther 2007;45(7):385-393