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[PUBMED Abstract] Scher HI, Chung LW: Bone metastases: improving the therapeutic index

Seek medical advice promptly for persistent gastrointestinal symptoms

doi: 10.1210/en.2011-1499 49 HaedersdalSLundAKnopFKVilsbollT

When estradiol levels rise due to fat-driven aromatization or conversion of excess external testosterone the brain senses enough sex hormone and slows down the axis: Less GnRH is released from the hypothalamus The pituitary releases less LH and FSH The testes produce less natural testosterone This negative feedback loop means men with obesity or on high-dose TRT may experience further suppression of their own testosterone production and long-term dependence on therapy

Peptides such as Kisspeptin-10 specifically target testosterone regulation

Liver Health: It is now used to treat MASH (liver scarring) caused by fatty liver disease