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Sirtuin-1 also has been reported to promote endothelial cell proliferation and suppress senescence of porcine primary aortic endothelial cells via a signaling mechanism requiring the expression of the serine-threonine kinase, LKB1, the upstream regulator of AMPK (179)

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doi: 10.2337/dc12-2454 72 RosenstockJHanefeldMShamannaPMinKWBokaGMiossecPet al