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Most AEs were mild in severity, and a higher proportion of participants reported an AE following administration of PF-06882961 at the 300 mg dose level, compared with other study treatments (Table S10)

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Its primary research application is as a pharmacological probe to selectively activate IGF1R in cell culture systems where IGFBP interference would otherwise complicate interpretation

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Those findings examined isolated berberine at specific dosages under controlled conditions

These figures represent average outcomes in controlled clinical trial settings and do not predict individual patient results