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JAMA Netw Open 2024;7:e2436783.ArticlePubMedPMC 30

Sulforaphane-rich cruciferous vegetables have been shown to modulate CYP3A4 activity and enhance aflatoxin B1 detoxification, which is particularly relevant for individuals with reduced-function CYP3A4 or GST/UGT variants.[ref][ref] On the conjugation side, phase II enzymes determine how quickly reactive mycotoxin intermediates are neutralized and excreted from the body

This can result in long-term weight management as their body is not constantly fighting to regain the weight back to the old higher set point