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Two data points were omitted from analysis in vehicle group due to extensive food spillage

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1 This insulin secretion causes an overall decrease in blood sugar levels, reduces the production of glucagon, which prevents the release of glucose storage from the liver, and induces a satiety response that elevates insulin sensitivity and causes weight loss

Tirzepatide carries a boxed warning regarding thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Upper arm injections fall somewhere between the two