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Ipamorelin selectivity research has consistently validated its minimal HPA axis stimulation compared to other synthetic secretagogues with studies documenting significantly lower cortisol and ACTH responses than GHRP-2 and GHRP-6 at equivalent GH-releasing doses establishing it as the preferred GHSR-1a agonist for research requiring clean GH axis selectivity

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This suggests a dampening of the reward response tied to eating

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