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Clinical Progress of Glutaminase Inhibitors Glutaminase inhibitors selectively target the overactive GLS in cancer cells, sparing GLS2 in normal cells: Blocking EMT (Epithelial-to-Mesenchymal Transition) : These inhibitors can help prevent EMT, which supports cancer spread
This helps your provider customize your starting dose and escalation timeline, potentially reducing nausea before it starts
Specifically, MOTS-c drives fatty acid oxidation, meaning your cells preferentially burn fat for fuel rather than storing it
These conditions affect up to 15 % of pregnancies and are recognised as one of the leading causes of maternal and fetal death globally (Reference Kassebaum, Barber and Bhutta99)
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