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For instance, the gain of function or loss of function mutations of transcriptional co-activators upregulate oncogenic transcriptional signaling, by facilitating permissive chromatin environment

doi: 10.1136/bmjdrc-2020-002083 54 MeurotCJacquesCMartinCSudreLBretonJRattenbachRet al

Pharmacokinetics TCAs undergo rapid absorption and are metabolised in the liver to mostly active metabolites, for instance amitriptyline is converted to nortriptyline

SLU-PP-332 Studied for its involvement in mitochondrial activity, metabolic flexibility, and cellular energy expenditure

While further research is needed, its potential to stabilize depigmentation and induce durable repigmentation makes it a promising option for vitiligo management (5)