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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

[DOI] [PubMed] [Google Scholar] 113.Vergote I., Finkler N.J., Hall J.B., Melnyk O., Edwards R.P., Jones M., Keck J.G., Meng L., Brown G.L., Rankin E.M., et al

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[CrossRef] [PubMed] [Google Scholar] Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental

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