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In the STEP-1 trial, published in the New England Journal of Medicine, adults on once-weekly semaglutide 2.4 mg lost about 14.9% of body weight on average over 68 weeks, versus about 2.4% on placebo [1]

Subcutaneous and intraperitoneal routes give shorter circulating windows, with the compound clearing primarily through proteolytic degradation outside the GI tract rather than through renal or hepatic elimination as a single molecule

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