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In this case, metformin has shown anti-angiogenic effects in a rotenone-induced model of PD which has been correlated to the neuroprotection of TH + neurons in the substantia nigra (El-Ghaiesh et al., 2020)

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The main isoforms ROCK1 and ROCK2 regulate multiple biological functions, including proliferation, differentiation, and migration by cytoskeletal reorganization

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