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10 Small-molecule drugs targeting BRAF or MEK kinases have been approved for the treatment of BRAF mutation in melanoma, including the immune checkpoint inhibitor Ipilimumab, selective type 1 BRAF: Vemurafenib and Dabrafenib and the MEK inhibitor Trametinib

Corticosteroids stimulate appetite centres in the hypothalamus, often causing marked increases in hunger and food-seeking behaviour

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others extend each dose level for an additional month to minimize nausea or digestive changes

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