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Vascul Pharmacol 2019;120:106565

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Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat

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Gonzlez Olmo BM, Butler MJ, Barrientos RM (2021) Evolution of the Human Diet and its impact on Gut Microbiota, Immune responses, and Brain Health

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1 None of them was living with type 2 diabetes

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Amylin's primary physiological functions include [11] : Slowing gastric emptying: Delays the rate at which food enters the small intestine, reducing post-meal glucose spikes Controlling glucose metabolism: Reduces inappropriate hepatic glucose output during meals Promoting satiety: Acts on area postrema in the brainstem to reduce food intake In type 2 diabetes, amylin secretion is impaired alongside insulin deficiency, contributing to postprandial hyperglycemia and dysregulated satiety [12]

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Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening

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