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This personalized approach reduces stomach pain incidence by up to 35% compared to standard one-size-fits-all dosing protocols, allowing more patients to achieve their weight loss goals without debilitating gastrointestinal side effects

Not Significant: Mean difference, 0.4 mL/kg/min [95% CI, 0.4 to 1.2 mL/kg/min]

Management Initial Treatment * Aggressive IV fluids (usually crystalloids) * Adequate analgesia (often opioids) * Oxygen if required * Antiemetics * Monitor urine output and vital signs Nutritional Support * Early enteral feeding preferred * Nasogastric or nasojejunal feeding if unable to tolerate oral intake Treat Underlying Cause * Gallstones: ERCP if cholangitis or persistent obstruction * Alcohol cessation counseling * Control triglycerides if elevated Antibiotics * Not routinely indicated * Reserved for infected pancreatic necrosis or confirmed infection Complications Local * Pancreatic pseudocyst * Pancreatic necrosis * Abscess * Hemorrhage Systemic * Shock * Acute respiratory distress syndrome (ARDS) * Acute kidney injury * Sepsis * Multi-organ failure * Gallstones and alcohol account for most cases

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