Unlike injectable GLP-1 medications such as Zepbound (tirzepatide) or Wegovy (semaglutide), Foundayo is a small-molecule, non-peptide drug
Greff, D
Unlike, GLP-1 and Gcg, GIP is not derived from preproglucagon and does not cause a reduction in body weight (Baggio and Drucker, An alternative approach aiming to maximize the efficacy of GLP-1 involves the delivery of nuclear receptor agonists to specific tissues characterized by the expression of GLP-1R
Tirzepatide's lower nausea rates compared to semaglutide supported this theory
This protocol requires the full escalation through 2mg, 4mg, 8mg, and 12mg over 12 to 24 weeks depending on the schedule chosen
Moreover, dulaglutide phosphorylated phospholamban at amino acid serine 16 which is the PKA phosphorylation site (Frank and Kranias 2000, Fig