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Weight loss was significant in outcome trials, ranging from a 0.6 kg reduction at 12 weeks in the ELIXA trial to a 4.3 kg reduction at 2 years with injectable semaglutide in the SUSTAIN-6 trial

Recent studies have highlighted the role of inflammation, oxidative stress, and hypoxia as key mediators that link OSAS with various comorbidities, such as cardiovascular disease, diabetes, and neurocognitive disorders [7,8]

Based on current evidence, GLP-1RAs are not recommended as first-line therapy for type 2 diabetic patients at high risk for colorectal cancer [47]

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collision energy) of metabolites were as follows

Ibrahim RB, Yeh SY, Lin KP, Ricardo F, Yu TY, Chan CC, Tsai JW, Liu YT