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At standard doses (100-200 mcg each), side effects are minimal and may include slight water retention, temporary fatigue as the body adapts, and vivid dreams due to enhanced deep sleep

Among the 4 DOACs, dabigatran is a direct and competitive thrombin inhibitor, 2 whereas the other 3 are factor Xa inhibitors ( Figure )

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Mobile phase A comprised a mixture of 40 mM sodium acetate and 17% methanol, while mobile phase B was 100% methanol