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UNDERSTAND THIS: The bodys synthesis of glutathione is tightly regulated by feedback inhibition of gamma-glutamylcysteine synthetase, meaning your endogenous system actively resists sustained elevation from exogenous dosing

Statements Author contributions TZ: Data curation, Formal Analysis, Investigation, Methodology, Writing original draft, Writing review & editing

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In addition to the gut-brain and gut-kidney axes, the gut microbiota systemically communicates through other axes such as the gut-liver (Albillos et al., 2020), gut-heart (Zhao et al., 2023), gut-skin (Sinha et al., 2021), and gut-bone (Zhang et al., 2024) axes, among others

Thus, if the cytosolic GSH concentration is approximately 7000 M, then the half life would be in the 23 hour range

The reduced expression of pykF in MG12345 led to an increase in the intracellular concentration of PEP and also caused an increase in the concentrations of G6P and F6P, which in turn decreased the glucose uptake rate