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Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

Injection technique follows standard subcutaneous protocols

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Li Z, Koban KC, Schenck TL, Giunta RE, Li Q, Sun Y

Pickart, L., & Freedman, J

Semaglutide is perhaps the most well-known, marketed as Ozempic for diabetes and Wegovy for weight management