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Comp Biochem Physiol C Toxicol Pharmacol (2006) 142:2319

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Collectively, these results suggest that ascites-mediated protection against ferroptosis is driven by decreased HMGCS2, leading to reduced fatty acid oxidation, increased lipid droplet accumulation, and enhanced resistance to ferroptosis

D.MazurM.TelserJ.2007Free radicals and antioxidants in normal physiological functions and human disease

Touliatos clinical experience, YK-11 is a particularly hepatotoxic SARM, which he has observed to cause hypertransaminasemia (high liver enzymes) on numerous occasions