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This pattern suggests DSIP's potential influence on the opioidergic system, possibly contributing to mechanisms of stress mitigation or adaptation

Why bedtime dosing is preferred Endogenous GH secretion in healthy adults is tightly tied to sleep architecture, with the largest spontaneous pulse occurring within the first 60 to 90 minutes of slow wave sleep

Dec 22 2020;22(1)doi:10.3390/ijms22010021

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Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K