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Good candidates typically have a BMI over 30, or a BMI of 27 or higher along with one or more weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol

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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite

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In people with T2DM and overweight or obesity, the preferred pharmacotherapy should be a glucagon-like peptide 1 receptor agonist (GLP-1 RA) or dual glucose-dependent insulinotropic polypeptide and GLP-1 RA with greater weight loss efficacy, especially considering their added weight-independent benefits (e.g., glycemic and cardiometabolic) [16]

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