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Patients who do not respond to GLP-1 therapy are becoming a growing concern in diabetes care, especially as GLP-1 receptor agonists continue to gain popularity for glycemic control and weight management

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SAVOR-TIMI with saxagliptin was the first to come out and there was absolutely no cardiovascular benefit

Conflating failed pharmacology with failed biology risks permanently sidelining therapeutically valuable systems, while indiscriminately resurrecting abandoned targets without rigorous criteria risks repeating historical mistakes

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Genetic Predictors of Response: Why One Option May Work Better for You Genetic variation in hormone receptors and appetite-regulating pathways significantly influences medication response