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Although the study did not distinguish the efficacy among different heterozygous LMP variants, it confirmed that heterozygous mutations in the LMP pathway (including MC4R ) are associated with compromised long-term surgical outcomes, consistent with the findings in heterozygous MC4R P/LP variant carriers

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Results: Patients diagnosed with DM1 who used long-acting NPH insulin (n = 4) compared to other types of slow-acting insulin (n = 23) showed lower insulin action sensitivity (p = 0.02)