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Modulao do sistema VEGF: Um dos mecanismos mais bem documentados a ativao da via do fator de crescimento endotelial vascular (VEGF)

Although the mutual node F583/F538 is not part of the binding site, it is specifically interesting since we previously reported that the point mutation F583A results in a long-range allosteric impact, that propagates across the membrane, rendering the protein inactive (Weigl et al., 2018

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