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Protein levels were detected using chemiluminescence (Bio-Rad, USA) and analyzed with ImageJ software (version 1.52)

Safety of resistance training in older adults and clinical populations Despite the benefits of RT on multiple physiological systems, particularly related to muscle mass and reducing the risk of frailty and loss of independence, as of 2018 only 19% of older adults report participating in muscle strengthening activities of any kind (Hyde et al., 2021)

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But access to safe, evidence-based treatment options remains critical

Meta-analyses of randomized trials corroborate these findings: one large review of 27 RCTs reported no significant difference in suicidality between GLP-1 RAs and placebo (RR 0.76) [48], while another meta-analysis including 25 trials similarly showed no association across multiple subgroups and endpoints (RR 0.84) [49]