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The work of Marcora and those who followed has shown that cognitive fatigue raises the perception of effort: at the same intensity, exercise "feels" harder, and the athlete stops sooner, even though the muscles could keep going

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Because retinopathy is estimated to take at least 5 years to develop after the onset of hyperglycemia, patients with type 1 diabetes should have an initial dilated and comprehensive eye examination within 5 years after the diabetes diagnosis (47)