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In vitro, 16-hour incubation of mouse primary pituitary cultures with CJC-1295 DAC produced a concentration-dependent increase in GH in the medium, and at 10 ng/mL caused DNA damage on comet assay together with increased H2AX expression, a marker of the double-strand-break response

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Duca FA, Ct CD, Rasmussen BA et al (2015) Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats