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In contrast, GPx2 focuses on the gut, acting as a barrier against oxidants from food, which is why its abundant in intestinal cells
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As a result, gastrointestinal TD may develop and exist as a steady-state, providing other tissues with thiamine levels sufficient for normal conditions, but inadequate for metabolic challenges
& Loscalzo, J
Sousa A, Azevedo R, Costa VM, et al