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GLP-1s can offer weight loss of more than 15% a substantial amount that could make a real difference to comorbidities associated with obesity, such as cardiovascular outcomes, Guirguis says

The October 2025 network meta-analysis reported a higher adverse-event relative risk for retatrutide (RR 4.10) than for tirzepatide (RR 2.78), consistent with higher GI burden at top doses 20

As body weight decreases, the dose of levothyroxine needed to maintain euthyroidism may change, typically requiring a reduction in thyroid hormone replacement

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Regulatory networks defining EMT during cancer initiation and progression