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It belongs to the drug class phosphodiesterase-5 (PDE-5) inhibitors which work by relaxing vascular smooth muscle and increasing blood flow in the penis to cause erection

Epub 2009 Mar 25

Translational Neurodegeneration 4:11

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NICD translocate to the nucleus, binds with the transcriptional repressor RBP-J, and leads to transcriptional activation (50)