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Once the patient is at a point where they're losing weight in a slow, consistent, healthy way, then we keep them on that dose until we've reached their goal weight, and then we slowly taper the medication off, Levites said

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2.2 Mechanism and causes Muscle functionality and contractility can suffer impairment either at or beyond the neuromuscular junction, termed peripheral fatigue, or proximal to it, referred to as central fatigue