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10.1038/s41584-024-01102-y 121 KrupkovaO.SmoldersL.Wuertz-KozakK.CookJ.PozziA
Because SLC7A11 exchanges intracellular glutamate with extracellular cystine, the intracellular glutamate concentration decreases, which leads to more Gln uptake and increased glutaminase activity and making these cells dependent on external Gln
The twice-weekly schedule during loading allows flexibility in choosing injection days and times based on convenience
Phentermine is FDA-approved for short-term use, meaning a few weeks at a time, not indefinitely
Glutathione is generally recognized as safe at supplemental doses (up to 1000 mg daily), though long-term safety studies are limited
At the end of the reaction, wash the resin with 200mLx3DMF, add 200mL DBLKx2 for deprotection 5min+7min, wash the resin with 200mLx5DMF, and continue to couple Fmoc-Gly-OH, Boc-Glu(OtBu)-OH, Fmoc-Leu-OH, Fmoc in sequence according to the peptide sequence -Tyr(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Val-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc-Phe-OH, Fmoc-Thr(tB
