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Panels A and B of Figure 1 show the steady state values for the male and female substrates, respectively, and the velocities for CBS, GS, and GPX
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The formation of the isopeptide bond between the -carboxyl group of glutamate and the -amino group of cysteine is catalyzed by the enzyme -glutamylcysteine synthetase
Activated HSCs also secrete matrix metalloproteinases (MMPs), whose activity is important in maintaining a balance between tissue repair and scar formation in hepatic fibrosis
The diagnosis usually involves the following: clinical findings, the finding of 5-oxoprolinuria, low levels of glutathione, low activity of glutathione synthetase, and mutation analysis of the glutathione synthetase gene
Many people begin with weekly glutathione infusion sessions for the first several weeks, then transition to bi-weekly or monthly treatments for ongoing maintenance
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