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Early research focused primarily on metabolic regulation

Despite initial pharmaceutical interest, AOD 9604 did not progress through the full clinical trial pathway required for regulatory approval, and it holds no Marketing Authorisation (MA) from the MHRA or EMA

More significant structural improvements reduced fine lines, improved firmness, better skin density typically become visible between weeks 8 and 12, with continued improvement through months 4 to 6 as collagen remodeling matures