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Here are some anecdotal comments from users on Reddit: A patient who jumped to 1.7 mg from 0.5 mg experienced severe nausea, vomiting, diarrhea, and sulfur burps, and decided to stay on the same dose to avoid the risk of further serious side effects

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USCs study reported $175 billion in cost offsets (not savings, as the USC study did not estimate what it would cost Medicare to cover GLP-1s) for Medicare over 10 years through GLP-1 coverage

These common side effects are typically mild and subside as your body adjusts to the medication

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There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form